解剖学和形态学
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行为科学
心脏和心血管系统
细胞和组织工程学
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牙科,口腔外科和医学
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泌尿学和肾脏学
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心理学,临床
abstract::Mycobacterial genomes contain large sets of loci encoding membrane proteins that belong to a family of multidrug resistance pumps designated Resistance-Nodulation-Cell Division (RND) permeases. Mycobacterial membrane protein Large (MmpL) transporters represent a subclass of RND transporters known to participate in the...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.13675
更新日期:2017-06-01 00:00:00
abstract::Trypanosoma cruzi, the etiologic agent of Chagas disease, has a complex life cycle in which four distinct developmental forms alternate between the insect vector and the mammalian host. It is assumed that replicating epimastigotes present in the insect gut are not infective to mammalian host, a paradigm corroborated b...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13653
更新日期:2017-06-01 00:00:00
abstract::Bacteria of the genera Bacillus and Clostridium form highly resistant spores, which in the case of some pathogens act as the infectious agents. An exosporium forms the outermost layer of some spores; it plays roles in protection, adhesion, dissemination, host targeting in pathogens and germination control. The exospor...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13650
更新日期:2017-05-01 00:00:00
abstract::Certain endospore-forming soil dwelling bacteria are important human, animal or insect pathogens. These organisms produce spores containing an outer layer, the exosporium. The exosporium is the site of interactions between the spore and the soil environment and between the spore and the infected host during the initia...
journal_title:Molecular microbiology
pub_type: 评论
doi:10.1111/mmi.13651
更新日期:2017-05-01 00:00:00
abstract::Peptidoglycan (PG), the major component of the bacterial cell wall, is one large macromolecule. To allow for the different curvatures of PG at cell poles and division sites, there must be local differences in PG architecture and eventually also chemistry. Here we report such local differences in the Gram-positive rod-...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13629
更新日期:2017-04-01 00:00:00
abstract::The bacterial flagellum contains a specialized secretion apparatus in its base that pumps certain protein subunits through the growing structure to their sites of installation beyond the membrane. A related apparatus functions in the injectisomes of gram-negative pathogens to export virulence factors into host cells. ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13623
更新日期:2017-04-01 00:00:00
abstract::The fungal pathogen Candida albicans can transition from budding to hyphal growth, which promotes biofilm formation and invasive growth into tissues. Stimulation of adenylyl cyclase to form cAMP induces hyphal morphogenesis. The failure of cells lacking adenylyl cyclase (cyr1Δ) to form hyphae has suggested that cAMP s...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13588
更新日期:2017-03-01 00:00:00
abstract::We identified interactions between the conserved bacterial replication initiator and transcription factor DnaA and the nucleoid-associated protein Rok of Bacillus subtilis. DnaA binds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promoters of several DnaA-regulated genes....
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13590
更新日期:2017-03-01 00:00:00
abstract::Advances in automated fluorescence microscopy have made snapshot and time-lapse imaging of bacterial cells commonplace, yet fundamental challenges remain in analysis. The vast quantity of data collected in high-throughput experiments requires a fast and reliable automated method to analyze fluorescence intensity and l...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13591
更新日期:2017-03-01 00:00:00
abstract::The insertion of proteins into the prokaryotic plasma membrane is catalyzed by translocases and insertases. On one hand, the Sec translocase operates as a transmembrane channel that can open laterally to first bind and then release the hydrophobic segments of a substrate protein into the lipid bilayer. On the other ha...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.13586
更新日期:2017-02-01 00:00:00
abstract::Disulfide bonds are found in many proteins associated with the cell wall of Escherichia coli, and for some of these proteins the disulfide bond is critical to their stability and function. One protein found to contain a disulfide bond is the essential cell division protein FtsN, but the importance of this bond to the ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13565
更新日期:2017-02-01 00:00:00
abstract::Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances in this area have identified numerous variations on the a...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.13532
更新日期:2017-01-01 00:00:00
abstract::Fungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulato...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13493
更新日期:2016-12-01 00:00:00
abstract::The assembly of the class 5 colonization factor antigen I (CFA/I) fimbriae of enterotoxigenic E. coli was proposed to proceed via the alternate chaperone-usher pathway. Here, we show that in the absence of the chaperone CfaA, CfaB, the major pilin subunit of CFA/I fimbriae, is able to spontaneously refold and polymeri...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13530
更新日期:2016-12-01 00:00:00
abstract::Various physiological stimuli trigger the conversion of noninfective Leishmania donovani promastigotes to the infective form. Here, we present the first evidence of the effect of glucose starvation, on virulence and survival of these parasites. Glucose starvation resulted in a decrease in metabolically active parasite...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13534
更新日期:2016-12-01 00:00:00
abstract::Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which catalyses its irreversible degradation. Herein, we describe the identifi...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13531
更新日期:2016-12-01 00:00:00
abstract::Avermectins produced by Streptomyces avermitilis are effective anthelmintic agents. The autoregulatory signalling molecule that triggers avermectin biosynthesis is a novel butenolide-type molecule, avenolide, rather than common γ-butyrolactones (GBLs). We identified AvaR2, a pseudo GBL receptor homologue, as an import...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13479
更新日期:2016-11-01 00:00:00
abstract::The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13484
更新日期:2016-11-01 00:00:00
abstract::Helicobacter pylori colonizes the human stomach and is a potential cause of peptic ulceration or gastric adenocarcinoma. H. pylori secretes a pore-forming toxin known as vacuolating cytotoxin A (VacA). The 88 kDa secreted VacA protein, composed of an N-terminal p33 domain and a C-terminal p55 domain, assembles into wa...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13443
更新日期:2016-10-01 00:00:00
abstract::Bacterial ribosome requires elongation factor P to translate fragments harbouring consecutive proline codons. Given the abundance of ORFs with potential EF-P regulated sites, EF-P was assumed to be constitutively expressed. Here, we report that the intracellular pathogen Salmonella enterica serovar Typhimurium decreas...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13454
更新日期:2016-10-01 00:00:00
abstract::Natural transformation is a potent driver for genetic diversification in bacterial populations. It involves exogenous DNA binding, uptake, transport and internalization into the cytoplasm, where DNA can be processed and integrated into the host chromosome. Direct visualisation of transforming DNA (tDNA) has been limit...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13440
更新日期:2016-09-01 00:00:00
abstract::The threonine dehydratase IlvA is part of the isoleucine biosynthesis pathway in the Gram-positive model bacterium Bacillus subtilis. Consequently, deletion of ilvA causes isoleucine auxotrophy. It has been reported that ilvA pseudo-revertants having a derepressed hom-thrCB operon appear in the presence of threonine. ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13429
更新日期:2016-09-01 00:00:00
abstract::Bacteria have obtained a variety of resistance mechanisms including toxin-antitoxin (TA) systems against bacteriophages (phages), whereas phages have also evolved to overcome bacterial anti-phage mechanisms. Dmd from T4 phage can suppress the toxicities of homologous toxins LsoA and RnlA from Escherichia coli, represe...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13420
更新日期:2016-09-01 00:00:00
abstract::The natural resistance of Mycobacterium abscessus to most commonly available antibiotics seriously limits chemotherapeutic treatment options, which is particularly challenging for cystic fibrosis patients infected with this rapid-growing mycobacterium. New drugs with novel molecular targets are urgently needed against...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13406
更新日期:2016-08-01 00:00:00
abstract::Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient molecules, perhaps even predating the existence of the translation machinery. Albeit old, these mole...
journal_title:Molecular microbiology
pub_type: 杂志文章,评审
doi:10.1111/mmi.13419
更新日期:2016-08-01 00:00:00
abstract::NADPH oxidases (Nox) produce reactive oxygen species (ROS) in multicellular eukaryotic organisms. They trigger defense reactions ('oxidative burst') - in phagocytes and plant cells -, and are involved in a broad range of differentiation processes. Fungal Nox-complexes play a central role in vegetative, sexual and path...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13391
更新日期:2016-07-01 00:00:00
abstract::Ethylenediaminetetraacetate (EDTA) is currently the most abundant organic pollutant due to its recalcitrance and extensive use. Only a few bacteria can degrade it, using EDTA monooxygenase (EmoA) to initiate the degradation. EmoA is an FMNH2 -dependent monooxygenase that requires an NADH:FMN oxidoreductase (EmoB) to p...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13363
更新日期:2016-06-01 00:00:00
abstract::Listeria monocytogenes FrvA (Lmo0641) is critical for virulence in the mouse model and is an ortholog of the Bacillus subtilis Fur- and PerR-regulated Fe(II) efflux P1B4 -type ATPase PfeT. Previously, FrvA was suggested to protect against heme toxicity. Here, we demonstrate that an frvA mutant is sensitive to iron int...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13368
更新日期:2016-06-01 00:00:00
abstract::The utilization of several sugars in Escherichia coli is regulated by the Phosphotransferase System (PTS), in which diverse sugar utilization modules compete for phosphoryl flux from the general PTS proteins. Existing theoretical work predicts a winner-take-all outcome when this flux limits carbon uptake. To date, no ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13329
更新日期:2016-05-01 00:00:00
abstract::The enteric gamma-proteobacterium Photorhabdus luminescens kills a wide range of insects, whilst also maintaining a mutualistic relationship with soil nematodes from the family Heterorhabditis. Pathogenicity is associated with bacterial exponential growth, whilst mutualism is associated with post-exponential (stationa...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13345
更新日期:2016-05-01 00:00:00
abstract::Engulfment of the forespore by the mother cell is a universal feature of endosporulation. In Bacillus subtilis, the forespore protein SpoIIQ and the mother cell protein SpoIIIAH form a channel, essential for endosporulation, through which the developing spore is nurtured. The two proteins also form a backup system for...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13311
更新日期:2016-04-01 00:00:00
abstract::The Frz pathway of Myxococcus xanthus controls cell reversal frequency to support directional motility during swarming and fruiting body formation. Previously, we showed that phosphorylation of the response regulator FrzZ correlates with reversal frequencies, suggesting that this activity represents the output of the ...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13323
更新日期:2016-04-01 00:00:00
abstract::A Lactobacillus casei BL23 strain defective in an OmpR-family response regulator encoded by LCABL_18980 (PrcR, RR11), showed enhanced proteolytic activity caused by overexpression of the gene encoding the proteinase PrtP. Transcriptomic analysis revealed that, in addition to prtP expression, PrcR regulates genes encod...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13299
更新日期:2016-04-01 00:00:00
abstract::Pseudomonas syringae pv. syringae cell densities fluctuate regularly during host plant colonization. Previously we identified nine genes dependent on the quorum-sensing-associated luxR homolog ahlR during epiphytic and apoplastic stages of host colonization. Yet their contributions to host colonization remain obscure,...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13289
更新日期:2016-03-01 00:00:00
abstract::In this study, we followed the genomic, lipidomic and metabolomic changes associated with the selection of miltefosine (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resistance to antimonial drugs (antimony sensitive strain Sb-S; and antimony resistant Sb-R). MIL-R was e...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13291
更新日期:2016-03-01 00:00:00
abstract::Each bacterium has to co-ordinate its growth with division to ensure genetic stability of the population. Consequently, cell division and growth are tightly regulated phenomena, albeit different bacteria utilise one of several alternative regulatory mechanisms to maintain control. Here we consider GpsB, which is linke...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13279
更新日期:2016-03-01 00:00:00
abstract::In almost all bacteria, cell division is co-ordinated by the essential tubulin homologue FtsZ and represents an attractive but as yet unexploited target for new antibiotics. The benzamides, e.g. PC190723, are potent FtsZ inhibitors that have the potential to yield an important new class of antibiotic. However, the evo...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13286
更新日期:2016-03-01 00:00:00
abstract::Conjugative transfer of toxin and antibiotic resistance plasmids in Clostridium perfringens is mediated by the tcp conjugation locus. Surprisingly, neither a relaxase gene nor an origin of transfer (oriT) has been identified on these plasmids, which are typified by the 47 kb tetracycline resistance plasmid pCW3. The t...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13270
更新日期:2016-03-01 00:00:00
abstract::Prior to the discovery of a minimal ATP-dependent DNA ligase in Haemophilus influenzae, bacteria were thought to only possess a NAD-dependent ligase, which was involved in sealing of Okazaki fragments. We now know that a diverse range of bacterial species possess up to six of these accessory bacterial ATP-dependent DN...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13229
更新日期:2016-01-01 00:00:00
abstract::Recently, we identified a novel disulfide oxidoreductase, SdbA, in the oral bacterium Streptococcus gordonii. Disulfide oxidoreductases form disulfide bonds in nascent proteins using a CXXC catalytic motif. Typically, the N-terminal cysteine interacts with substrates, whereas the C-terminal cysteine is buried and only...
journal_title:Molecular microbiology
pub_type: 杂志文章
doi:10.1111/mmi.13227
更新日期:2016-01-01 00:00:00